Crockpot Mississippi Meatloaf Recipe
Introduction
This Crockpot Mississippi Meatloaf is a comforting, flavorful twist on a classic dish. Slow-cooked to juicy perfection with tangy pepperoncini peppers and savory seasoning packets, it’s an effortless meal perfect for busy days.

Ingredients
- 2 pounds ground beef (90/10)
- 1 cup panko bread crumbs
- 1 cup milk
- 2 eggs
- 2 (1 ounce) ranch dressing seasoning packets
- 2 (1 ounce) au jus gravy mix packets
- 1 tablespoon minced dried onion
- 2 cups water
- 6-8 pepperoncini peppers
- Optional: 1 tablespoon chopped fresh parsley (for garnish)
Instructions
- Step 1: In a large bowl, mix together the ground beef, panko bread crumbs, milk, eggs, one ranch seasoning packet, one au jus gravy mix packet, and minced dried onion until just combined.
- Step 2: Whisk the remaining ranch and au jus seasoning packets with the water, then set this mixture aside.
- Step 3: Line the bottom of a 5-quart (or larger) slow cooker with foil, then spray it with cooking spray to prevent sticking.
- Step 4: Shape the meat mixture into a loaf and place it on the foil in the slow cooker.
- Step 5: Pour the prepared water and seasoning mixture over and around the meatloaf, then add the pepperoncini peppers to the slow cooker.
- Step 6: Cover and cook on low for 6 hours, or on high for 3-4 hours, until the meatloaf reaches an internal temperature of 165°F (74°C).
- Step 7: If desired, garnish with chopped fresh parsley before serving.
- Step 8: Serve the meatloaf warm over mashed potatoes or rice and enjoy your hearty meal.
Tips & Variations
- Use 80/20 ground beef for a richer flavor and slightly juicier meatloaf.
- For extra flavor, add a splash of Worcestershire sauce to the meat mixture.
- Consider topping the cooked meatloaf with a slice of cheese during the last 15 minutes of cooking for a melty finish.
- Substitute pepperoncini peppers with mild banana peppers if you prefer less heat.
- If you don’t have ranch or au jus packets, try making your own seasoning mixes with garlic powder, onion powder, beef bouillon, and dried herbs.
Storage
Store any leftover meatloaf in an airtight container in the refrigerator for up to 3 days. To reheat, warm slices gently in the microwave or in a skillet over low heat until heated through. You can also freeze cooked meatloaf tightly wrapped for up to 3 months; thaw overnight in the fridge before reheating.
How to Serve

Serve this delicious recipe with your favorite sides.
FAQs
Can I use a different type of ground meat?
Yes, you can substitute ground turkey or chicken for a lighter version, but the meatloaf may be less juicy. Adding a bit of olive oil or a small amount of ground pork can help maintain moisture.
Do I need to line the slow cooker with foil?
Lining the slow cooker with foil makes cleanup easier and prevents the meatloaf from sticking. You can skip this step if you generously spray the slow cooker with cooking spray, but using foil is recommended for best results.
PrintCrockpot Mississippi Meatloaf Recipe
A flavorful and easy-to-make Crockpot Mississippi Meatloaf featuring ground beef mixed with ranch and au jus seasoning, slow-cooked to perfection with tangy pepperoncini peppers for a juicy, tender result. Perfect for a comforting weeknight dinner served over mashed potatoes or rice.
- Prep Time: 15 minutes
- Cook Time: 3-6 hours
- Total Time: 3 hours 15 minutes to 6 hours 15 minutes
- Yield: 6–8 servings 1x
- Category: Main Dish
- Method: Slow Cooking
- Cuisine: American
Ingredients
Meatloaf Mixture
- 2 pounds ground beef (90/10)
- 1 cup panko bread crumbs
- 1 cup milk
- 2 eggs
- 2 (1 ounce) ranch dressing seasoning packets, divided
- 2 (1 ounce) au jus gravy mix packets, divided
- 1 tablespoon minced dried onion
Slow Cooker Mixture
- 2 cups water
- 6–8 pepperoncini peppers
- Cooking spray (for greasing foil)
Optional Garnish
- 1 tablespoon chopped fresh parsley
Instructions
- Prepare the Meatloaf Mixture: In a large bowl, combine the ground beef, panko bread crumbs, milk, eggs, 1 packet of ranch seasoning, 1 packet of au jus gravy mix, and minced dried onion. Mix gently until just combined to avoid tough meatloaf.
- Mix the Cooking Liquid: In a separate bowl, whisk together the remaining ranch packet, au jus gravy mix packet, and 2 cups of water. Set this mixture aside.
- Prepare the Slow Cooker: Line the bottom of a 5-quart or larger slow cooker with foil. Spray the foil generously with cooking spray to prevent sticking.
- Shape and Place Meatloaf: Form the meat mixture into a loaf shape and place it on the foil inside the slow cooker.
- Add Liquids and Peppers: Pour the water mixture over and around the meatloaf in the slow cooker. Add 6 to 8 pepperoncini peppers around the meatloaf for flavor and moisture.
- Cook the Meatloaf: Cover the slow cooker and cook on low for 6 hours, or on high for 3 to 4 hours, until the meatloaf is thoroughly cooked and reaches an internal temperature of 165°F (74°C).
- Garnish and Serve: Optionally garnish the meatloaf with chopped fresh parsley. Serve warm, ideally over mashed potatoes or rice for a hearty meal.
Notes
- Using panko breadcrumbs gives a lighter texture than regular breadcrumbs.
- Cooking times may vary depending on your slow cooker model; always check internal temperature.
- Adjust the number of pepperoncini peppers for more or less tangy heat according to your taste.
- For a lower fat option, use leaner ground beef or substitute part of the beef with ground turkey.
- Leftovers can be stored in an airtight container in the fridge for up to 3 days or frozen for up to 3 months.
Keywords: Mississippi meatloaf, crockpot meatloaf, slow cooker dinner, easy meatloaf recipe, pepperoncini meatloaf

